Yard Sale is a dark comedy about two estranged sisters, Opal (Katie Ryan) and Ruby (Dana Fares), who return to their childhood home to bury their late mother. Opal is the older of the two, an uptight and organized control freak who always plays by the rules. Ruby, on the other hand, is a free spirit, always going with the flow and never taking anything too seriously.
Despite their differences, the sisters must come together to plan a funeral and pay for the expenses. As they go through their mother's belongings, they discover she had accumulated an immense amount of debt and left them with no inheritance. With no other options, they decide to hold a yard sale to pay for her funeral.
The sisters meet various characters from their mother's past: unexpected neighbors, an old fling, and a group of eccentric friends who reveal a side of their mother the sisters never knew. They also confront their own issues and past traumas, as they navigate selling their mothers belongings, rekindling their relationship and trying to find a way to say goodbye.